A systems biology approach to study tissue movements in mouse embryonic stem cell spheroids during germ layer self-organization
We invite talented and motivated students to apply for the InPhInit Caixa Fellowship program to do a Phd at the "Self-Organization of Biological Systems" laboratory under the supervision of Dr. Luciano Marcon.
The successful candidate will work in the emerging field of organoid biology investigating the morphogenetic movements observed during germ layer self-organization in mouse embryonic stem cell spheroids. The student will work in a multidisciplinary laboratory and will received training both in wet lab and modeling. He/She will work with mouse embryonic stem cell cultures and will generate different reporter cell lines by using CRISPR/Cas9. The project will be based on a systems biology approach that combines experiments, 3D lightsheet microscopy and computational modeling to identify which cellular behaviors underlie the gastrulation-like movements observed during spheroid development.
The PhD will be carried at the Gene Expression and Morphogenesis Unit (GEM) at the Andalusian Centre for Developmental Biology (CABD), in the charming city of Seville, southern Spain. The research center offers a dynamic environment with close interaction with other groups working on Mouse, Zebrafish, Xenopus, Drosophila and Caenorhabditis development. Candidates should submit their application trough the InPhInit website.